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ea0099oc7.4 | Oral Communications 7: Endocrine-related Cancer | ECE2024

Single-nucleus atlas of adrenocortical carcinoma reveals tumor ecotypes associated with outcome

Assie Guillaume Jouinot Anne , Martin Yoann , Foulonneau Thomas , Bendjelal Yanis , Violon Florian , Calvet Philip , Izac Brigitte , Letourneur Franck , Bertholle Celine , Andrieu Muriel , Onifarasoaniaina Rachel , Favier Maryline , De Guitaut Charlene , Fraikin Archibald , De Murat Daniel , Armignacco Roberta , Benanteur Nesrine , Sibony Mathilde , Perlemoine Karine , Bonnet Fideline , Gaillard Martin , Dousset Bertrand , Pasmant Eric , Barat Maxime , Dohan Anthony , Haissaguerre Magalie , Tabarin Antoine , Libe Rossella , Guignat Laurence , Groussin Lionel , Berthon Annabel , Ragazzon Bruno , Bertherat Jerome , Assie Guillaume

Background: Bulk genomic studies have identified distinct molecular classes of adrenocortical tumors (ACT). Transcriptome profiles separate benign ACT (“C2” cluster) from carcinomas (ACC) and identify two groups of ACC, “C1A” (“steroid” and “proliferation” signatures) and “C1B” (“immune” signature), of poor and better prognosis respectively. However, these signatures were characterized at the tissue level (“bulk&...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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